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|We are an emerging research group studying the human microbiome, in particular the microbiota of the oral cavity. We are a multidisciplinary group, in which every idea is taken into account. We work with the latest technology, at a research center committed to give full support to research in areas related to public health, in a great city to live, full of green areas, close to the beach and with privileged climate.|
|The Oral Microbiome Laboratory|
The Oral Microbiome Laboratory: Overview and Training Capacity
The Human Microbiome Laboratory is directed by Dr Alejandro Mira and was created in the year 2008 at the Center for Advanced Research in Public Health, integrated within the FISABIO Foundation. The group is part of the Genomics and Health Department, where 50 researchers work on the development of "omics" and high-throughput sequencing techniques for the study of infectious diseases. Dr Mira is in charge of studying the human microbiome and its contribution to health and disease, especially the oral microbiota. He has directed six national grants on the topic, as a consequence of which five patents have been registered, including new probiotic and prebiotic compounds to prevent oral diseases, a new diagnostic test that indicates a personalized treatment to prevent tooth decay and a method to diagnose colorectal cancer by the use of microbial biomarkers. One of these patents has already been licensed and has been approved in the EU and 12 other countries.
The group has performed the first metagenomic, metatranscriptomic and metaproteomic studies of human dental plaque in the world, the first of which allowed them to win the Biomedal Research Award for the best molecular biology publication of 2011-2012, awarded by the Spanish Society of Microbiology. They have performed some of the first metagenomic studies on the breast milk microbiome, the lung microbiome and the stomach microbiome. The laboratory has also developed a new in vitro model to study the development of biofilms and therapeutic treatments, which can be visualized in real time, and that has been proposed to improve antibiotic treatment of infections in human implants. The group has discovered a new bacterial species that is being developed as a probiotic to include in functional foods. Animal trials have been successful and three clinical trials for the use of the probiotic in humans were performed in 2017 and 2018. The project to develop the probiotic has received the National FIPSE Award in Health Innovation in 2018.
Dr Mira's group is formed by four PhD students, a Master student, a technician and four post-doctoral researchers. All members of the group receive a mixed training in experimental and bioinformatic techniques and all group computers use Linux operating system. The group trains regularly 1-2 undergraduate students every year and directs one Master thesis and one First Degree final project every course.
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"Oral Microbiome Lab is a Scientific Unit for Business Innovation (UCIE) funded by the Valencian Innovation Agency (AVI), through the PREVECAM project (Development of preventive and diagnostic methods against diseases caused by microorganisms). This type of Units are co-financed by the European Regional Development Fund of the European Union. For more information about this type of actions, click here:
Juntos podemos encontrar soluciones para los problemas de Salud Pública
Haciendo un donativo al CSISP, estás ayudando al desarrollo de proyectos de investigación en salud pública en campos tan diversos como el cáncer, sida, hepatitis, enfermedades cardiovasculares, osteoporosis, etc.